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The intestinal epithelium together with gut-associated lymphoid tissue and the neuroendocrine network work at regulating transport of environmental or dietary antigens from the intestinal lumen into the sub-mucosa.[2] Dysregulation of the mucosal barrier leads to leakiness of antigens and other macromolecules into the host to initiate systemic inflammation and immune activation which in turn influences tolerance and immunity

Albrecht, R

Nevertheless, at the end of the 1980s, suitable techniques were available that enabled small quantities of albumin to be measured that were not measurable with earlier techniques

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