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Netter's Internal Medicine

Being a potential potent inhibitor of LRRK2 kinase activity with low risk for off-target side effects, Vit B12 supplementation in patients with PD (PwPD) seems appealing and encourages future clinical trials to investigate this potent effect as such evidence remains restrained to animal models (Green and Christine 2019) (Fig

Inositol: Much like methionine, this B-vitamin helps metabolize fats and reduce cholesterol

However, a few limited studies have raised concerns about the possible side effects of taking vitamin B12: A 2019 study found that taking more than 25 micrograms (mcg) per day or higher was associated with an increased risk of bone fractures in postmenopausal women