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Global metabolic profiling of animal and human tissues via UPLC-MS

In human, TMAO is mainly derived from gut, where the gut microbiota converts dietary nutrients into TMA, which is absorbed into the bloodstream through the intestinal mucosa, and then transformed into TMAO by hepatic flavin monooxygenases (FMOs) in the liver (Zeisel and Warrier, 2017

References Cited Ahmet U, Abdurrahman K, Sait B, Ahmet E, Salih D, Mendane S, Ates Y, Fatih B, Necmettin K, Kemal D

However, testicular sections from the BPA 100 group showed seminiferous tubules with moderate vacuolation, degeneration, and necrosis of the spermatogenic epithelium