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BPDE DNA adducts were also determined in the placenta of smoking mothers [8]

4.5 Stress In recent years, extensive research has confirmed that stress plays a critical important role in the pathogenesis of IBS, not only by directly affecting the activation and regulation of the hypothalamic-pituitary-adrenal (HPA) axis but also by altering the gut microbiota, disrupting the epithelial barrier, and activating local immune responses, further exacerbating visceral hypersensitivity and triggering or worsening IBS symptoms (116)

5 However, its most important antioxidant effect is thought to be as a precursor for glutathione (GSH), 6 a tripeptide made from the amino acids glutamate, glycine and cysteine, and the bodys major antioxidant

10.3390/su15021225 21 ChenH.ZhuB.ZhaoL.LiuY.ZhaoF.FengJ.et al (2018)
