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Indeed, an intact VN appears necessary for certain antisteatotic reflexes: leptin's ability to reduce liver fat depends on vagal signaling to stimulate triglyceride export from the liver, further highlighting the vagal role in lipid metabolism (Metz et al

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Copper is an essential cofactor for numerous key enzymes involved in tissue remodeling, including lysyl oxidase (which cross-links collagen and elastin fibers), superoxide dismutase (the primary intracellular antioxidant enzyme), and cytochrome c oxidase (the terminal enzyme of mitochondrial respiration)

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