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The reaction consumes the universal cellular methyl donor SAM and the NAD + salvage precursor nicotinamide, producing a metabolite (1-MNA) that is excreted in urine
The scientists concluded that Epitalons geroprotective activity is attributed to its capacity to restore epiphyseal melatonin production through the modulation of human clock gene expression [108]
Gastroenterology, 112 , 398408
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