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These have important physiological roles against OS, inflammation, and apoptosis (Pae et al., 2008)
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doi: 10.1093/glycob/cwq054, 186 YangL.LiuS
In the RESPITE trial, riociguat proved to be a viable alternative for patients with PAH not responding to PDE5 inhibitors because of reduced endogenous NO production (Hoeper et al., 2017a)
