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1D), we assume that greater lysosomal acidity increases LLOMes effects on the lysosomal membrane in Lyso-high GBM cells

In this study, MOR triggered prolonged endosomal Gi/o signalling via trafficking of activated G proteins, independent of receptor internalization, revealing a distinct mechanism of endosomal GPCR signalling

Additionally, some patients may experience paradoxical worsening or develop new chemotherapy-induced peripheral neuropathy (CIPN) after BTZ discontinuation, a phenomenon known as coasting, which can lower survival rates, particularly in children and adolescents (Tay et al., 2022