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BPC 157 and Standard Angiogenic Growth Factors: Gastrointestinal Tract Healing, Lessons from Tendon, Ligament, Muscle and Bone Healing. Current Pharmaceutical Design

10.1007/s00430-021-00727-0 [DOI] [PMC free article] [PubMed] [Google Scholar] 334.Hsu R-J, Yu W-C, Peng G-R, Ye C-H, Hu SY, Chong PCT, et al

We found that lactate, taken up and oxidized by the mitochondrial cluster of differentiation 147 (CD147)/monocarboxylate transporter 1 (MCT1)/lactate dehydrogenase B (LDHB) complex, was converted into the tricarboxylic acid (TCA) cycle intermediate -ketoglutaric acid (-KG), which subsequently induced MIC stemness potentials via DNA methyltransferase 3 beta (DNMT3B)-mediated SOX2 hypomethylation

Shimano H, Sato R