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While DC-derived IL-12 triggers Th1-driven eye inflammation, DC-sourced IL-1, IL-6, and IL-23 are responsible for the generation of Th17 cell-dependent injury in meibomian and lacrimal glands

298.Alsady M, Baumgarten R, Deen PM, et al

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Interestingly, both citrate 63,64 and ASP 38 have gained a lot of attraction in recent years due to their rate-limiting effect on tumour cell proliferation, and inhibition of the ASP-ASN metabolic pathway in acute lymphoblastic leukaemia (ALL) is the first example of a tumour-metabolism-targeting therapy 65