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Both point mutations and alanine substitution of the serine and threonine residues from 375 to 379 (STANT sequence) has been indicated to markedly decrease the agonist-induced recruitment of -arrestin and receptor internalisation

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Jun 2015;31(3):166-172.

Spotted fever and other tick-borne diseases are increasing in prevalence as the range of ticks expands, which is likely impacted by climate change 8
