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(4) combining drug delivery with local CSF removal ("pharmacodialysis") to clear the affected/treated tissue
[DOI] [PMC free article] [PubMed] [Google Scholar] 442.Wells SA Jr, Robinson BG, Gagel RF, Dralle H, Fagin JA, et al
Toxicity evaluations demonstrate an IC50 above 300 g/mL for joint cells and no adverse effects in 28-day in vivo studies
