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Description
Although increasing the cohort size above six results in little increase in the probability of observing a given event, the higher the sample size the greater the probability for observing an event that is not due to a study drug but is simply part of the spontaneous event rate for that event

This is the basis for twice-daily dosing

[DOI] [PubMed] [Google Scholar] 300

This additionally helps depart time for delivery in case the costume takes longer than expected to reach
