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Inhibition of fat production AOD 9604 inhibits adipogenesis through the following mechanisms: Inhibition of adipocyte differentiation: AOD 9604 can down-regulate the expression of peroxisome proliferator-activated receptor (PPAR) and CCAAT/ enhancer binding protein (C/EBP), and block the differentiation of preadipocytes into mature adipocytes

Some patients may require imaging studies (ultrasound, CT scanning) or referral to hepatology, haematology, or oncology services

for MetS and T2D), and because exercise is one of the most potent IGF-1 synthesis/freeing mechanisms, it seems logical to correlate them and establish IGF-1 as a target for future options in the multifactorial treatment for metabolic syndrome

Approach Short trial arm Duration 12 weeks Review Point Week 12 Notes METAOD005 used 12 weeks at oral doses 1-30 mg/day in 300 obese adults