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Improved Bioavailability via NDDS Oral administration of drugs might be problematic due to their low solubility and poor permeability

During semaglutide therapy, metabolic shifts and rapid changes in glucose handling may increase cellular oxidative burden, potentially worsening nausea and other systemic reactions

[DOI] [PMC free article] [PubMed] [Google Scholar] 135.Mitchell S., Vargas J., Hoffmann A

the stability was measured using the HPLC method: column Kromasil 100, 5 , 150x4.6 mm, mobile phase 0.1% triflouroacetic acid in water/acetonitrile (from 0 to 50 vol.%), gradient elution in 25 minutes, flow 1 ml/min, detection: UV at 214 nm
