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To surmount the adverse effects of long blood sample transport times from the zoo to the laboratory on sample quality, we established a vaccine-specific interferon- (IFNG) release-based, point-of-care whole blood stimulation assay that can be carried out and preserved at the trial site for subsequent gene expression analysis, starting with measuring IFNG as a correlate of T cell activation

Jayaprakash et al

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As a result, the redox state of the heme iron determines the capacity of -globin to bind to NO