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According to NICE guidance, hydroxocobalamin injections are the recommended first-line treatment for pernicious anaemia and other malabsorption-related deficiencies
The three lead compounds, 78c (IC50 7.3 nM), 1ai (IC50 46nM), and Iah (IC50 115nM), increased NAD levels in muscle and liver of diet-induced obese mice [78-79]

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