glutathione mitochondrial density Glutathione-dependent redox balance characterizes the distinct metabolic properties of follicular and marginal zone B cells Glutathione Metabolism and the Novel

JCI Insight 3(22), 2018

The overexpression of this enzyme in the astrocytes of glial fibrillary acidic protein-heme oxygenase-1 (GFAP-HMOX1) transgenic mice resulted in increased subcortical oxidative imbalance with the induction of mitochondrial damage and autophagy, augmented dopamine and serotonin levels in the basal ganglia, and reduced dopamine 1 receptor (D1) in the nucleus accumbens, and enzyme overexpression caused degeneration of axons in the hippocampus and hyperkinetic behavior [44]

It is also important to note that free radical damage can lead to abnormal DNA, a condition that may contribute to the onset of NCDs

doi: 10.1016/j.bcp.2004.05.042 Summary Keywords COVID-19, vitamin B12, epidrugs, chromatin remodeling, DNA methylation, epigenetic markings, inflammation, antiviral response Citation Cassiano LMG, Cavalcante-Silva V, Oliveira MS, Prado BVO, Cardoso CG, Salim ACM, Franco GR, DAlmeida V, Francisco SC and Coimbra RS (2023) Vitamin B12 attenuates leukocyte inflammatory signature in COVID-19 via methyl-dependent changes in epigenetic markings