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All research subject gave written information consent prior to inclusion in the study, and all human studies were approved by the Cleveland Clinic institutional review board

It is known that TBK1 phosphorylates serine residues near the LIR of ubiquitin-binding adapter proteins, including OPTN, to enhance binding affinity toward LC3 via conformational alteration and subsequent avidity effect 29

Plant cells do not contain cholesterol but instead contain other sterols called phytosterols

Unabsorbed fatty acids can reach the colon, where they may stimulate water secretion and increase intestinal motility, resulting in loose stools or diarrhoea