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It is also beneficial for individuals with chronic conditions such as tendonitis or muscle strains, as well as for those looking to improve muscle strength

It demonstrates that various dietary nutrients, including plant- and animal-based proteins, fats, and diverse mineral elements, influence depressive mood primarily through post-ingestive regulation of gut microbiota

When administered as a nasal spray, it could bypass the blood-brain barrier, allowing the peptide to act directly on brain tissues

Hence, further prospective studies addressing the incidence of DPN in relation to the degree of vitamin B12 deficiency per daily and cumulative doses of metformin in each therapeutic period are necessary to clarify the complex relationship between metformin treatment, vitamin B12 deficiency, and DPN occurrence in T2D (173) ( Box 3 )