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In diabetes mellitus, oxidative stress is increased and ROS are produced at an elevated rate, resulting in a cascade of events: reduced NO increased prothrombotic factors including tissue factor, and plasminogen activator inhibitor-1 increased endothelin-1, resulting in thrombosis and vasoconstriction, and increased nuclear factor kappaB and activation protein 1, which leads to ED [52]

The catch is that they are biologically active peptides, not a passive ingredient

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