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A multidisciplinary strategy that integrates biostatistics, machine learning, and sperm epigenome sequencing with clinical and lifestyle data may improve reproductive diagnostics and personalized treatment strategies (152)

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doi: 10.1104/pp.123.1.335 11 BartoliC

44 While there was no clear evidence of withdrawal hemolysis associated with the VOCs occurring during the clinical trials in SCD, a sudden stop in drug dosing due to noncompliance or side effects could theoretically translate into an abrupt increase in 2,3-DPG levels and a consequent shift of the oxygen dissociation curve to the right, promoting an acute increase in deoxy-HbS polymerization, sickling, and vaso-occlusion