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While all GSTZ1-1 variants are inactivated by DCA, one variant, which has lysine instead of glutamic acid at position 32 and arginine instead of glycine at position 42 of the protein, is more rapidly inactivated than other variants in the presence of physiological concentrations of chloride

Various one-pot synthesis-based PROTACs with different aliphatic, aromatic and rigidified heterobifunctional linkers were synthesized, demonstrating the suitability of one-pot transformation for high-throughput screening

Since S is natively an IDP in solution, bearing little to no ordered structure, rational design of compounds to stabilise the monomeric, non-toxic conformation is difficult

& Tannock, I