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Holling et al., 2004

Activation of mTORC1 signaling has been found to inhibit the interaction between lysosomal NPC1 and mitochondrial translocator protein (TSPO), resulting in the untethering of mitochondria-lysosome contact sites and cholesterol accumulation, indicating that mTORC1 serves as a central component of lysosomal signaling, mediating cholesterol trafficking from lysosomes to mitochondria by modulating the interaction between NPC1 and TSPO (Lin et al., 2023)

mir200 family) resulting in enhanced oxidative stress and cytotoxicity

Additionally, glycine is an agonist for glycine-gated chloride channels that are expressed by a range of tissues peripherally and in the central nervous system.24-28 Activation of glycine-gated chloride channels has a depolarizing impact on cells that actively accumulate chloride and a hyperpolarizing impact on those that do not