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Upon stimulation with LPS and IL-1, HUVECs and trophoblast cells exhibited significantly increased expression of IL-6, IL-8 and MCP-1, but when ESM1 was knocked down using small interfering RNA, the stimulatory effect of IL-6, IL-8 and MCP-1 expression was diminished in both cell types (85), as depicted in Fig
This makes them more effective than oral supplements, particularly for individuals with digestive concerns or nutrient deficiencies

That literature is substantial in volume and consistent in direction but it has important limitations that are not always acknowledged in consumer-facing content
