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Therefore, investigating whether palmitoyl-L-carnitine accumulation driven by cardiovascular and other metabolic diseases, plays a fundamental role in age-related conditions could provide insights into its potential as a biomarker for underlying systemic metabolic disruptions

The MTHFD2 enzyme is resistant to inhibition by NADH and so this reaction can contribute to significant mitochondrial NADH production under increased serine catabolism as well as during periods where the major NADH producing catabolic pathways are inhibited by increasing NADH levels

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After refeeding for 24 h, both average volume and number of DHS-3::GFP positive lipid droplets recovered (Fig