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Moreover, oxidative stress upregulates adhesion molecules like intercellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1) on orbital fibroblasts and endothelial cells, facilitating immune cell recruitment and adhesion to inflamed orbital tissue (88, 89)

Ferroptosis in NAFLD: insights and the therapeutic potential of exercise

There is evidence for immune system dysfunction in FM, with altered levels of cytokines/chemokines and growth factors and other inflammatory biomarkers in the brain and spinal fluid indicating neuroinflammation may play a potential role [100,101]

Moreover, current literature suggests that gut microbiome is a strong contender in metformin therapy and the microbiome-regulated mechanisms involving alterations in the gut microbiota composition influence its pleiotropic effects (Pryor et al., 2019