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Solution: CRISPR-engineered humanized metabolic strains (e.g., CYP3A4 knock-in) integrated with physiologically based pharmacokinetic (PBPK) modeling (Wong et al., 2017)

Kellermann* Head Science P Page 341 and 342: Masahito Hirota National Research I Page 343 and 344: Satoshi Kitajima Japan Sea National Page 345 and 346: Natsuko Nakayama Harmful Algal Bloo Page 347 and 348: Hiroya Sugisaki Research Management Page 349 and 350: yasunori Watanabe Seikai National F Page 351 and 352: Chang-Hoon Kim Department of Marine Page 353 and 354: Min Kyung Shin Department of Marine Page 355 and 356: Olga N

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Nevertheless, cells with an SOCE deficiency are more susceptible to oxidative stress