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However, further research is needed to elucidate the underlying mechanisms and establish optimal doses

The GSDMD N-terminal structural domain (GSDMD-N) is generated by the cleavage of GSDMD proteins by pro-inflammatory caspases through classical and non-classical inflammasome signaling pathways

FIGURE 1 Confounding effects of dexamethasone on the ROR of fluoroquinolone-induced tendinopathy Evaluation of confounding effects of drug combinations on the ROR of tendinopathy in a population of fluoroquinolone users in FAERS, JADER, and CVARD revealed that many concomitantly used drugs affected the ROR of fluoroquinolone-induced tendinopathy (Figures 2AC and Supplementary Data S2)

The extrinsic apoptosis pathway also plays a pivotal role in the pathogenesis of CD