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Notably, elevated TMAO concentrations induce oxidative stress and activate the NOD-like receptor thermal protein domain associated protein 3 (NLRP3) inflammasome in human fetal colon cells, suggesting that TMAO triggers inflammasome activation and promotes an inflammatory response in the intestinal endothelium (17)

In this Review, we describe the evidence for abnormalities in energy metabolism and mitochondrial function in migraine, with a focus on clinical data (including neuroimaging, biochemical, genetic and therapeutic studies), and consider the relationship of these abnormalities with the abnormal sensory processing and cerebral hyper-responsivity observed in migraine

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doi: 10.1016/j.cmet.2012.06.001 119 WangHJPochampalliMWangLYZouJXLiPSHsuSCet al