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Description
Unfortunately, due to the inability caused by previously mentioned second and third limitations, dozens of them mostly fail in ARDS clinical trials (S et al., 2015)

Santos AM, Lopes T, Oleastro M, Gato IV, Floch P, Benejat L, Chaves P, Pereira T, Seixas E, Machado J, et al

& Cho, N.-J
Tolerance is defined as the reduction in the effects of a drug following its prolonged administration, leading to the loss of drug potency and the increase in dosage to maintain its analgesic effects (8)
