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The inhibition of mitochondrial bioenergetic function by hyperoxia results in mitochondrial dysfunction, evidenced by a reduced membrane potential (Audi et al
(2004) Insulin-like growth factor-I receptor signalling and acquired resistance to gefitinib (ZD1839
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Despite multimodal interventions (surgery, radiotherapy, chemotherapy), median overall survival is generally reported as 46 months, with only 1020% of patients surviving past one year [124]
