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The E3 ligase functions to correctly orientate the E2-loaded ubiquitin and the substrate protein and, in so doing, facilitates the ubiquitination of the substrate, in which an isopeptide bond is formed between ubiquitin and the -amino group of a lysine residue within the substrate

All experimental procedures were performed in accordance with the requirements of the Animal Ethics Committee of the Tongji Medical College, Huazhong University of Science and Technology

Beauty from Within: Adequate B12 levels are proven to reduce hair loss, strengthen nails, and give your skin a healthy, vibrant glow

An evaluation of the impact of smoking on the effectiveness and metabolism of antituberculosis medications is also conducted