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Therapeutic targeting of immune-inhibitory and stimulatory pathways can alter the immune systems tolerance for self, resulting in damage to normal cells, known as immune-related adverse events (irAEs)

The increasing level of complexity from the molecular (pigments and protein) to supramolecular (photosystems) level mirrors the necessity of different time-scale responses (from seconds to months) to modulate light that is (inevitably) absorbed

Since cognitive dysfunction is a core feature of depression, often persisting even after mood improves, the cognitive enhancement properties of Semax provide additional therapeutic value