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This study aims to test the hypothesis that the antioxidant effect of the synthetic tetrapeptide AEDG (Ala-Glu-Asp-Gly, Epitalon) improves the delayed healing process associated with hyperglycemia in DR, using a high glucose (HG)-injured human retinal pigment epithelial cell line (ARPE-19)

FSR GSH was not significantly different, but the absolute synthesis rate of GSH (ASR GSH ) tended to be higher in the infants studied on day 2 [8.1 2.7 mg/(kg d) versus 10.6 2.4 mg/(kg d), p = 0.054]

Its concentration reflects cellular redox status and capacity to neutralize hydrogen peroxide through GPx

Medical Economics Company, Montvale, NJ Polonsky J (1973) Quassinoids bitter principles