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Heliyon 7, e08057

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Despite the distinct metabolic zonation signature of the in vivo liver, many standard 2D and 3D culture systems overlook the metabolic heterogeneity of the 3 distinct zones largely due to the complexity of the generation of an in vitro zonated model (Dash et al., in vitro liver model more widely available, we have modeled fluid flow and oxygen transport within the chambers of a Quasi-vivo 900 system 1