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Zheng X, Ji N, Campbell V, et al
Knockdown of nitric oxide synthases (NOS) will decrease the NO concentration which sensitized cell to ferroptosis [54, 55]
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In contrast, studies have demonstrated that the inhibition of glutamine metabolism in cancer cells using the DON precursor drug DRP-104 results in an augmentation of the number of NK and NK T-cells within the immune microenvironment, thereby enhancing anti-tumor immunity [121]
