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As such, elevated plasma 27-OHC has been associated with major depressive disorder as a result of impaired serotonin signaling, hypothalamicpituitaryadrenal (HPA) axis dysregulation and hippocampal neurotoxicity (Daray et al., 2018

Cell-based protein degradation assays HEK293T and U2OS were obtained from ATCC and cultured in high-glucose-containing Dulbeccos Modified Eagles Medium (DMEM

the result is a haze, color shift, or visible precipitate within hours

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