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136 In addition, acquired astrocytopathies are prominent in hepatic encephalopathy (in which astrocytes lose their homoeostatic capabilities 137 ) and in neuromyelitis optica, in which the astrocyte protein, AQP4 is the subject of autoimmune attack, leading to dysfunction and death of astrocytes resulting in pronounced inflammation and degeneration of neural tissue

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These can lead to side effects or reactions that you may then associate with the B12 itself, even though B12 has nothing to do with them