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"The effects of human growth hormone and its lipolytic fragment (AOD9604) on lipid metabolism following chronic treatment in obese mice and beta(3)-AR knock-out mice." Endocrinology Publication confirming the effectiveness in body weight reduction and the mechanism of action

Abrupt cessation wont cause withdrawal symptoms or rebound effects, but metabolic markers will gradually return to baseline over 24 weeks as AMPK activity normalizes and NNMT inhibition wears off

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However, our study suggests that FUT2, through its regulation of the cross-talk between gut microbes and the human host, might explain a part of the observational association between serum vitamin B12 and BMI