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Commercially Available GLP- 1 Receptors Agonists for the Management of T2DM Exenatide- Short Acting Agents The first GLP- 1 receptor agonist used in clinical practice was exenatide, which was injected subcutaneously twice a day

References 1.Lucke J.C., Bell S.K., Partridge B.J., Hall W.D

The demonstrated importance of protecting the terminals to pharmacokinetic characteristics suggests numerous additional synthetic approaches that may be applicable including the insertion of non-peptide linkages between the first and second amino acids, the replacement of the N~terminal amino acid with a non-a amino acid, and N-terminal acylation
