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Specifically, we will describe the paradigm change involving the role of bifunctional penicillin-binding proteins (aPBPs) and SEDS/bPBP pairs, and discuss in detail recent studies of RodA/PBP2 and FtsW/PBP3, the SEDS/bPBP pairs that drive PG synthesis in the elongasome and divisome, respectively

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Immunoaffinity-based techniques, which target exosome-specific surface markers such as those mentioned before, offer an alternative approach for isolating highly pure exosomes

2,8,15-17 The serotonin-norepinephrine reuptake inhibitor (SNRI) duloxetine is considered the first-line agent for treatment of CIPN