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Description
In schizophrenia (SZ), Down Syndrome, and bipolar disorder (BD), increased brain insulin resistance and reduced IGF-1 signaling drive allostatic load/overload, leading to physiological dysregulation and the presentation of more severe symptoms throughout the body [44,45,46]
However, none of these candidates could be confidently assigned as canonical catalase homologs based on sequence similarity criteria
Holoendemic means that the disease appears early in life and affects most of the population, as in malaria or hepatitis A and B in some regions
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