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Physical and Psychological Effects of Gynecomastia Gynecomastia, or enlarged breast tissue in men, can have both physical effects like breast swelling and tenderness, and significant psychological impacts including low self-esteem, anxiety, depression, body image issues, and social withdrawal, often stemming from feelings of embarrassment and perceived masculinity loss due to the altered body appearance

All statistical analyses were performed with JMP Pro software version 14 (SAS Institute Inc.)

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