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Melatonin is a hormone primarily involved in signaling the onset of sleep in response to darkness

Future studies are still needed to further clarify the causal relationships of amino acid metabolism in autoimmune diseases and its hierarchical position in immune regulation through more systematic genetic studies, metabolic flux analyses, and single-cell multi-omics approaches, so as to distinguish its specific role as a disease driver or as a passenger/metabolic marker

Advances in human cellular mechanistic understanding and drug discovery of brain organoids for neurodegenerative diseases

Heterogeneity of phenotype, nucleic acid content and chromatin structure