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Across the six published trials, the most common adverse events were headache, mild gastrointestinal effects (diarrhea, flatulence, nausea), nasopharyngitis, fatigue, dizziness, and mild injection-site reactions

As shown in Figure 5, left ventricular contractile dysfunction and arterial vascular disease are significant contributors to the development of hypertension, suggesting a potential pathway through which NNMT may influence hypertension

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