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Reactive oxygen species (ROS) with metalloprotease ADAM17 induce the release and transport of Notch intracellular domain (NICD), which in turn translocates into the nucleus and are directly involved in the transcriptional regulation of nuclear target genes that result in fibrotic processes, as proven by the expression of Col-I and SMA in ectopic lesions of patients with DIE [60]

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Mistake 3: Not tracking intake and symptoms A dual-peptide protocol requires more careful monitoring than monotherapy