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2026;4:1010132 DOI: Received: July 20, 2025 Accepted: March 18, 2026 Published: April 13, 2026 Academic Editor: Amnart Poapolathep, Kasetsart University, Thailand The article belongs to the special issue Neuroprotective Potential of Natural Products from Foods Aim: This study evaluated the comparative effects of commonly consumed artificial and natural sweeteners on cognitive function, neurotransmitter-related enzyme activities, and oxidative stress status in the brains of Wistar rats to elucidate their potential neurotoxic or neuroprotective properties under sub-chronic dietary exposure

While there is no definitive evidence documenting a drop in melatonin production in the aging RPE cells, in the pineal gland where melatonin has been most thoroughly investigated relative to age, it exhibits a marked reduction in old rodents (220) and with the evidence showing that this also occurs in the human pineal gland (221, 260262)

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