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It was found that urinary miRNA profiles were altered in rats after administration of a toxic dose of APAP

[232] [198] In addition to presynaptic actions that regulate DAT, TAAR1 activation exerts a somatodendritic inhibitory influence on midbrain dopamine neurons by reducing their firing rate via G protein-coupled inwardly-rectifying potassium channels, an effect that is expected to reduce action potential-dependent (vesicular) dopamine release into the synaptic cleft

Quantification and statistical analysis All data presented are expressed as arithmetic mean SEM