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The 24-week trials allowed for assessment of several long-term safety considerations
Liu KY, Mistry RJ, Aguirre CA, Fasouli ES, Thomas MG, Klamt F, Ramsden DB, Parsons RB (2015a) Nicotinamide N -methyltransferase increases complex I activity in SH-SY5Y cells via sirtuin 3
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[3] Subsequent structural optimization introduced the N-terminal tyrosine residue, yielding the compound now designated AOD-9604
